"Every cell is a library. We are only beginning to learn how to read."
About
Elspeth Cavendish joined Aldenmoor in 2017 following postdoctoral fellowships at the MRC Laboratory of Molecular Biology in Cambridge and the Weizmann Institute in Israel. She holds a European Research Council Consolidator Grant for her work on disordered protein regions and their role in the onset of neurodegenerative disease.
Her laboratory — the Cavendish Group for Molecular Dynamics — currently employs twelve researchers. The group’s 2022 paper in Nature Structural & Molecular Biology on TDP-43 aggregation dynamics was named among the journal’s top ten most-cited papers of the year.
Current research
- Mechanisms of phase separation in intrinsically disordered proteins relevant to ALS and FTD.
- Cryo-EM characterisation of early aggregation intermediates at atomic resolution.
- Development of small-molecule chaperones to inhibit pathological protein-protein interactions.
- Computational prediction of liquid–solid phase transitions in disordered protein systems.
Research Interests
- Molecular Biology
- Protein Folding
- ERC Grant Holder
